The each label in the proper position to designate the organ system is given below.
Nervous
Faster communication
Electrical
Basic life support (breathing, circulation are largely regulated by nervous system)
Cell to cell communication (neuron connect to other neurons/cell by synapse)
The CNS is made of the mind and spinal wire. The peripheral apprehensive gadget is made of nerves that department off from the spinal wire and amplify to all components of the body.
Endocrine
Slower
Chemical only
Blood transport
Utilize hormone
Growth
Gametes
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cawhich one of these is a polymer of glucose that we (animals) can convert back into glucose monomers if needed?
When necessary, animals like us may break down the glucose polymer known as glycogen back into its monomer form.
Both fungi and animals use the glucose polymer known as glycogen to store energy. The primary glucose storage type in the body is shown by the polysaccharide structure of glucose. The cells of the liver and muscles create and store glycogen while being hydrated with the four parts of water. It functions as a long-term energy storage reserve. Glycogen in muscles is quickly transformed into glucose by muscle cells, whereas liver glycogen does the same for the entire body, including the central nervous system.
Glycogen is a long polymer chain of glucose molecules joined by an alpha-acetal bond.
This acetal bond is created when the alcoholic and carbonyl groups combine. If the carbonyl group is an aldehyde group i.e(-CHO) and also termed as hemiacetal if there is a ketonic group. The acetal group is what results from the bonding of two alkoxy groups to the same carbon atom.
The complete question is:-
Which one of these is a polymer of glucose that we (animals) can convert back into glucose monomers if needed?
-fructose-6-phosphate
-glycogen
-fructose-2,6-bisphosphate
-fructose
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dental infections can lead to serious complications, since veins in the head and neck generally lack valves that prevent the backflow of blood. group of answer choices a. both the statement and the reason are correct and related. b. both the statement and the reason are correct but are not related. c. the statement is correct, but the reason is not correct. d. neither the statement nor the reason is correct.
Dental infections can develop in the tooth or its supporting structures and then spread to the nearby tissues. The head and neck region primarily lacks venous valves. It has been discovered that it can be challenging to identify and treat early face and dental infections.
What happens if a tooth infection is not treated?The harmful bacteria in your mouth can cause infections when your dental health is neglected and poor oral hygiene is practiced. An untreated tooth infection (abscess) can eventually make you ill.
What makes tooth infections more likely for me?Tooth infections are more likely to occur in those with diabetes, compromised immune systems, and those on particular drugs. Dental infections can spread to the surrounding tissues after starting in the tooth or its supporting structures.
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How could an error during transcription affect the protein that is produced apex.
The error during transcription affects the protein that is produced by (B) The protein would be made of the wrong nucleic acids.
The process of producing mRNA out of a DNA molecule takes place in the cellular nucleus and is known as transcription. The RNA polymerase enzyme is used to mediate the process. The messenger RNA, or mRNA, transmits genetic data or genetic codes, which are later used in the translation process to produce proteins.
Codons, which are aligned with genetic information, forecast the amino acids and, in turn, the protein that will be created. Therefore, a transcription error denotes a change in base pairs, which further denotes a change in codons, and then different amino acids, which would ultimately result in the production of an erroneous protein.
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Answer: The protein could be made of a wrong nucleic acid
Explanation:
The protein produced is altered by the transcriptional mistake. The incorrect nucleic acids would be used to make the protein.
Transcription, which takes place in the cellular nucleus, is the process of converting a DNA molecule into mRNA. The process is mediated by the RNA polymerase enzyme. In order to generate proteins, the messenger RNA, or mRNA, transmits genetic information or genetic codes. Codons predict the amino acids and, consequently, the protein that will be produced since they are in line with genetic information. As a result, a transcription error indicates a change in base pairs, which further indicates a change in codons, followed by different amino acids, which would finally produce an incorrect product.
q6.4 what problem would most likely occur if a haploid cell attempted to perform perform meiosis? a)the cell cannot replicate its dna prior to meiosis. b)the cell could not pair homologous chromosomes during meiosis i. c)the cell will produce diploid daughter cells.
The correct option is B ; The cell could not pair homologous chromosomes during meiosis. Haploid cells do not perform meiosis because in meiosis separation of sister chromatid occurs and in the haploid cell, sister chromatid is not present.
In the haploid cell, the number of chromosomes is already half. In metaphase I, the spindle protein is attached to the same chromatid during the time of congress ion. the division of chromosomes could not be done due to absence of sister chromatid.
In this condition, the cell cycle does not process and stops at the quiescent phase.
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if there are 50 flowers, 30 red (rr), 15 pink (rr) and 5 white (r), how many recessive alleles is in the population?
About 25 recessive alleles are there in the flower population.
The genetic diversity of a population at equilibrium can be determined using the Hardy-Weinberg equation. This equation is given by, p²+2pq+q² = 1.
Where p² is the frequency of homozygous dominant, q² is the frequency of homozygous recessive, 2pq is the frequency of heterozygous, p is the frequency of the dominant allele, and q is the recessive allele frequency.
Given, p² is 30, 2pq is 15, and q is 5. We have to find the frequency of homozygous recessive.
q² = 5² = 25
Therefore, the answer is 25. The correct option is option d.
The complete question is -
If there are 50 flowers, 30 red (RR), 15 pink (Rr) and 5 white (r), how many recessive alleles is in the population?
a)5 b)10 c)20 d)25
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Genes that code for a specific protein can be inserted into bacterial plasmids, and then the plasmids are used to transform cells. Many useful human proteins are now synthesized by these transgenic bacteria.
Uses for the synthesized proteins include human insulin used to treat diabetes and human growth hormone used to treat dwarfism
2) Which tenet of cell theory BEST serves as a basis for this type of biotechnology?
A) All living things are made up of cells.
B) All cells come from pre-existing cells by division.
The cell is the structural and functional unit of all living things.
D) Cells contains hereditary information which is passed from cell to cell during cell division
I think the best tenet of cell theory that describe this molecular biotechnology is that cell contains hereditory information which is passed from cell to cell during cell division because plasmid is an extrachromosomal genetic material of bacteria which replicates,divide along with bacterial division and hence each bacteria then possess this new hereditory material and hence increase amount of useful products like insulin.
which labeled structure is in charge of editing and sorting incoming sensory stimuli, and controlling information entry into the cerebral cortex?
Thalamus is in charge of editing and sorting incoming sensory stimuli, and controlling information entry into the cerebral cortex.
What is thalamus?
The brain's primary relay center is the thalamus. This central structure is traversed by motor pathways, limbic pathways, and sensory pathways other than olfaction.
s of the world's top ten percent of the world'ss of the world's greatest or to' the Each nucleus has distinct input routes and a variety of output projections, the majority of which communicate with the cerebral cortex.
The thalamus, a pair of egg-shaped structures located beneath the brain, has evolved to become larger and more complicated (like the cerebral cortex), and as mammals broke away from reptiles, its wiring grew considerably more complex.
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Tn response to falling blood glucose levels, which pancreatic islet cell releases glucagon?
The pancreatic beta islet cells react to a drop in blood sugar levels by releasing glucagon.
What is glucagon?Glucagon is a synthetic hormone that is used to treat very low blood sugar levels in diabetics who are taking insulin. This drug can also be used to help facilitate radiological examination of the digestive tract.
Beta cells (β Cells) are a type of cell found in the islets of the pancreas that synthesize and secrete insulin. Beta cells account for about 50-70% of the cells in the islets of the pancreas in the human body. The insulin hormone functions to lower blood sugar levels.
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an immunoassay was developed to rapidly diagnose patients infected with an emerging virus. however, the researchers discovered that some individuals were producing false negatives when tested, despite being infected with the virus. what might explain this? a) rapid evolution of the viral antigen b) changes in the length of the viral dna c) number of genome copies carried in each virion d) changes in the antibody produced by thevirus
Despite having the virus, they passed the test. the viral antigen has evolved quickly (option a).
How to describe a virusA length of nucleic acid (either DNA or RNA), encased in a protein coat, makes up a virus, an infectious bacterium. Since viruses are unable to multiply on their own, they must infect host cells in order to utilise those cells' components as building blocks for their own replication.
Where do viruses come from?Adaptable genetic components that could migrate across cells may have given origin to viruses. They could be the offspring of once-free-living creatures that developed a parasitic reproduction strategy. Perhaps viruses were present before cellular life evolved and were responsible for this.
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Why is the summer solstice the longest day of the year?
Answer:
because it is the day when the sun travels its longest path in the sky, allowing for the longest period of daylight to occur during one day each year.
Explanation:
hoped this helped:)
how many dna molecules would there be after four rounds of pcr if the initial reaction mixture contained two molecules?
The number of DNA ( Deoxyribonucleic acid) molecules that are produced after 'n' number of pcr ( polymerase chain reaction) can be given by the formula: N = d x 2ⁿ
where,
'N' is the number of DNA molecules obtained after 'n' number of polymerase chain reactions.
'd' is the number of DNA molecules originally present before the start of pcr cycle.
In the given question,
d = 2;
n = 4;
Then, N = 2 x 2⁴
N = 2 x 16
N = 32;
Thus, the number of DNA molecules that are obtained after 4 rounds of pcr when 2 molecules are present before the start of the process are 32.
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Submerged aquatic vegetation (SAV) plays a key role in supporting populations of fish and crabs in the shallow portions of the Chesapeake Bay and the rivers that flow into it. There are many species of underwater plants that make up SAV beds. Use what you know about photosynthesis and cellular respiration to explain why SAV beds are critical to the health of fish and crabs that live in the Chesapeake Bay. Use evidence and scientific reasoning to support your answer.
Submerged aquatic vegetation which is also called underwater aquatic plants play a key role in the survival of fish and crustaceans due to the products of photosynthesis, such as oxygen.
What is photosynthesis?Photosynthesis is the process in which green plants use a green pigment called chlorophyll to make their food by using energy from sunlight.
The result of photosynthesis is oxygen, which in turn is used by aquatic animals such as fish and crabs for cellular respiration.
Underwater plants consist of aquatic plants that grow completely underwater. Aquatic animals produce oxygen as a byproduct of photosynthesis to survive.
Underwater plants can be found in both fresh and salt water.
Therefore, aquatic plants play a key role in the survival of fish and crustaceans due to the products of photosynthesis, such as oxygen.
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What is translation in relation to proteins?
Translation is the process used for protein synthesis.
The translation is one of the processes in the central dogma of life by which information in the RNA is translated to produce protein. During this process, first, the mRNA, ribosomes, and tRNA form an initiation complex.
The codons in the mRNA will be read by tRNA. And tRNA will bring particular amino acid for that code. This continues till the tRNA reaches the stop codon of the mRNA. In this way, amino acids are added and joined with the help of peptide bonds to form proteins. So, translation is the process used to synthesize protein in the cell.
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Give the number of total electron groups, the number of bonding groups, and the number of lone pairs for the geometry depicted in (a).
The number of bonding groups and the number of lone pairs in geometry depicted in a, it can be 4 electron groups, 4 bonding groups, and 0 lone pairs.
How do you find the number of bonding electron groups?Lone pair of electron is nonbonded pair, nonbonded electron pair. A valence shell electron pair associated with one atom, and not part of a covalent bond.The difference between bond pair and lone pair is that a bond pair is composed of two electrons that are in a bond whereas a lone pair is composed of two electrons that are not in a bondHere steps for counting bonding electron pairs in a Lewis Structure:
First step is, count each single line as one bonded pair of electrons.Second step, count each double line as two bonded pairs of electrons.Third step, count each triple line as three bonded pairs of electrons.And the last, add up the numbers from each step.Learn more about electron groups here: brainly.com/question/29659721
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The half-reaction that occurs at the cathode during electrolysis of an aqueous sodium iodide solution is.
Answer: answer is below
Explanation:Reaction equation showing ionization of NaI is as follows. Reaction equation showing ionization of water is as follows. At cathode, only reduction reactions take place. Hence, reactions taking place at cathode are as follows. = -2.71Standard reduction potential equation for hydrogen ions is as follows. = 0.00 If a cation has more negative reduction potential then that ion is difficult to reduce as compared to the cation that has lower negative reduction potential.As has less electronegative reduction potential than .Thus, will be reduced easily and you will get the product at cathode.
what is being measured in this investigation to determine the rate at which photosynthesis is occurring? what conclusions can you make as the lamp intensity was increased? (use specific values from the investigation to support your answer.) what conclusions can you make as the temperature was increased? (use specific values from the investigation to support your answer.)
Measurement of CO2 uptake by plants: Since CO2 is required for photosynthesis, determining how much of it is taken up by plants can tell us how much photosynthesis is taking place.
What occurs when the brightness of the light is increased?The rate of photosynthesis increases as light intensity rises, but only until another factor—a limiting factor—becomes scarce. Until another factor becomes limiting, the rate of photosynthesis is directly proportional to the amount of light.
What occurs when the temperature rises?The kinetic energy of molecules increases with temperature. The likelihood of the reaction happening is raised by the molecules' increased movement and frequency of collisions. The reaction rate is accelerated by this.
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which medication directly inhibits osteoclasts, thereby reducing bone loss and increasing bone mass density (bmd)?
Calcitonin(Miacalcin) directly inhibits osteoclasts, thereby reducing bone loss and increasing bone mass density (BMD).
Osteoclasts are directly inhibited by calcitonin, which reduces bone loss and raises BMD. Raloxifene lowers the risk of osteoporosis by maintaining BMD without affecting the uterus estrogenically. The FDA recently gave teriparatide the go-ahead to treat osteoporosis. Calcium is more readily absorbed when vitamin D is present.
Calcitonin is a nasal spray and injection used to treat Paget's disease of the bones, excessive calcium, and osteoporosis in postmenopausal women. It's not a first-choice treatment option, despite being offered in a less expensive generic form.
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a man with hemophilia (a recessive, sex-linked condition) has a normal daughter, who marries a normal man. what is the probability that a daughter will be a hemophiliac? a son? if the couple has four sons, that all will be affected?
Answer:
read explanation
Explanation:
suppose the daughter has the reccesive gene and so does her husband the chances are aproximatly 25% in that case one of the 4 sons will be affected
unlike bacterial infections, populations of pathogenic viruses do not evolve resistance to antiviral drugs.
Unlike bacterial infections, populations of pathogenic viruses do not evolve resistance to antiviral drugs. The above statement is false.
Antiviral drug resistance is a growing concern in populations of immunocompromised patients because persistent viral replication and extended drug exposure select resistant types of viruses. By correlating distinctive viral mutations with resistance to different medications as identified by phenotypic testing, rapid diagnosis of resistance can be achieved. Optimizing host variables and medication delivery, choosing alternate treatments based on an understanding of the processes underlying resistance, and creating novel antivirals are all components of managing drug resistance.
This article talks about hepatitis B and herpesvirus drug resistance. Antiviral drug resistance is a growing concern in populations of immunocompromised patients because persistent viral replication and extended drug exposure select resistant types of viruses. Associating typical viral mutations with resistance to specific medications as revealed by phenotypic testing allows for the quick detection of resistance.
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sprawl can impact the environment by causing fragmentation of open space and wildlife habitat. true false
It is true that sprawl can have an adverse effect on the environment by dividing up open space and wildlife habitat.
A defensive manoeuvre used in reaction to specific takedown attempts, usually double- or single-leg takedown attempts, is referred to as a sprawl in martial arts and wrestling. In order to land on the upper back of the opponent attempting the takedown, the sprawl is executed by scooting the legs backwards. Urban sprawl has been linked to rising energy consumption, pollution, and traffic congestion as well as a loss of community identity. Poor water quality has been linked to a number of detrimental health outcomes, such as cancer, kidney illness, and gastrointestinal disorders. Deforestation and the destruction of wildlife habitat are two more negative environmental effects of sprawl in addition to air and water pollution. Urban sprawl, a specific type of urban growth, is a major contributor to many of the problems that cities face today. These issues include the production of greenhouse gases, air pollution, traffic jams, and a lack of affordable housing.
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in a 3-point cross, crossovers that occur during the formation of which gametes can be scored using the phenotype of f2 progeny?
In gametes generated by F1 tri-hybrids and gametes produced by parents from true-breeding populations.
When non-sister chromatids of homologous chromosomes exchange genetic material during meiosis, novel allelic combinations are created in the daughter cells. The locations of three genes in the genome of an organism are identified using a three-point cross. A homozygous recessive individual is crossed with a person who is heterozygous for three mutations, and the progeny's phenotypes are graded. When F1 progeny are self-pollinated, a 3:1 ratio of F2 progeny are created.
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mutation in the fibroblast growth factor receptor (fgfr) gene results in achondroplasia (dwarfism), which is a dominant condition caused by a single base substitution (ggg>agg) that changes the amino acid glycine at position 480 to arginine (g480r) in the fgfr protein. normally, fgfr is active when fgf binds to it and inhibits excessive bone growth, but the mutant fgfr is constantly active even when fgf is not bound to it. how can you create a mouse model for achondroplasia?
The FGFR3 gene has genetic point mutations that cause achondroplasia, a condition marked by faulty cartilage growth-plate differentiation and insufficient bone development.
Which of the following conditions is brought on by a FGFR3 mutation?
Thanatophoric dysplasia, a severe skeletal condition characterized by incredibly small limbs and a narrow chest, has been linked to mutations in the FGFR3 gene.
What binds to and activates fibroblast growth factor (FGF)?
Heparin-binding polypeptides called fibroblast growth factors (FGFs) play key roles in numerous critical developmental processes, including tissue patterning. FGFs work by attaching to particular intracellular kinase-containing FGF receptors (FGFRs).
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The characteristic that determines which generation in plants is dominant is the generation that:
a) is diploid
b) is haploid
c) carries out the majority of photosynthesis
d) produces the most gametes
The function that determines which era in flora is dominant is the technology option C. which includes the majority of photosynthesis.
The sporophyte is the dominant generation, however multicellular male and lady gametophytes are produced inside the flora of the sporophyte.
Dominant trends are the ones that are inherited unchanged in a hybridization. Recessive developments turn out to be latent or disappear, in the offspring of a hybridization. The recessive trait does, however, reappear within the progeny of the hybrid offspring. An instance of a dominant trait is the violet-flower trait.
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What is the difference between active and passive transport across a membrane?
A
Both active and passive transport move substances down their concentration gradients.
B
Active transport is ATP dependent. Passive transport does not require energy.
C
Active transport requires cell to cell communication. Passive transport does not require cell communication.
D
Active transport can be performed without transport proteins while passive transport cannot.
Active transport is ATP dependent. Passive transport does not require energy.
Cells require some molecules to be transported across the membrane. Transported molecules can be a waste material or it can be a metabolic product. Membrane transport are of two types active and passive transport. Active transport uses energy from hydrolysis of ATP to transport molecules across membranes. Active transport moves molecules from regions of low concentration to regions of high concentration. Special membrane proteins perform active transport for example sodium potassium pumps. Passive transport does not require energy to transport molecules since it moves molecules from regions of high concentration to regions of low concentration. Passive transport is of two types: simple diffusion and facilitated diffusion.
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The chitin in the walls of the tracheae has a similar chemical bonding and function as cellulose in plant cell walls. Explain how the chemical bonding in chitin enables it to carry out this function in insects. [3]
An analogy is a similarity due to convergent evolution, resulting in similar adaptations.
a. True
b. False
The statement that An analogy is a similarity due to convergent evolution, resulting in similar adaptations is true.
Analogy is similarity due to convergent evolution. Convergent evolution occurs when certain environmental pressures and natural selection produce similar adaptations in organisms from different evolutionary lineages. All organisms have derived their traits from the ancestors. They can either be homologous or analogous. Homologous structures have a similar embryonic origin but on the other hand analogous organs have a similar function. Convergent evolution simply signifies the fact that organisms with different ancestral origin, over a period of time adapt to perform certain similar functions. For example, the wings of birds and butterflies are adapted to perform the function of flight, flippers of Penguins and Dolphins to swim etc.
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Place the following labels in order indicating the passage of light through the eyeball. Vitreous humor Lens Ante Posterior chamber Tunica vasculosa Poste Anterior chamber Cornea Vit Tunica interna Tur Pupil Tuni Reset
The correct order indicating the passage of light through the eyeball is described below:
CorneaAnterior ChamberPupil Posterior Chamber Vascular Tunic LensVitreous Humor RetinaHow does light pass through the eyeball?Light first enters through the cornea and passes through the anterior chamber, which is a fluid-filled space between the cornea and pupil.
The light then passes through the pupil and into the posterior chamber, which is also filled with fluid. From there, it enters the vascular tunic, or middle layer.
The light then passes through the lens and vitreous humor to the retina which converts the light to an electrochemical signal.
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m protein, hyaluronidase, collagenase, and often a capsule, can be virulence factors for certain pathogenic strains of:________
M protein, hyaluronidase, collagenase, and often a capsule, can be virulence factors for certain pathogenic strains of streptococcus.
Virulence is the ability of an organism to infect a host and cause disease. Virulence factors are the cellular structures that enable microbial pathogens to achieve that as well as several things, such as:
Evading the host's immune response.Immunosuppression.Obtain nutritions from its host.Colonization of a niche in its host.Gain entry and exit out of cells.These factors can be used to either assist and promote colonization or bring damage to the bost.
Virulence factors can appear in many forms. Some pathogens are chromosomally encoded, while others obtain their factors from mobile genetic elements like bacteriophages.
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Put the enzymes of the first half of the citric acid cycle in order from left to right.
a. α-ketoglutarate dehydrogenase
b. citrate synthase
c. isocitrate dehydrogenase
d. aconitase
citrate synthase, aconitase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase is the correct order.
What are the steps of citric acid cycle?Step 1:
The two-carbon acetyl group (from acetyl CoA) is combined with a four-carbon oxaloacetate molecule in the first step to create a six-carbon citrate molecule. The sulfhydryl group (-SH) that CoA is linked to diffuses away and finally joins with another acetyl group. Due to its strong exergonic nature, this action cannot be undone. The availability of ATP and negative feedback both affect how quickly this reaction proceeds. The pace of this process reduces as ATP levels rise. The rate increases when ATP is scarce.
Step 2:
As citrate is transformed into its isomer, isocitrate, it loses one water molecule and gets another.
Step 3 and 4:
Isocitrate is oxidized in step three, resulting in the formation of the five-carbon molecule -ketoglutarate, a molecule of CO2, and two electrons that decrease NAD+ to NADH. ADP's beneficial effect and the negative feedback from ATP and NADH both influence this process. By releasing electrons that convert NAD+ to NADH and carboxyl groups that release CO2 molecules, steps three and four are both oxidation and decarboxylation processes. The results of steps three and four are -ketoglutarate and a succinyl group, respectively. To create succinyl CoA, CoA binds to the succinyl group. ATP, succinyl CoA, and NADH all function as feedback inhibitors, which control the enzyme that catalyses step four.
Step 5:
Coenzyme A is replaced with a phosphate group, and a high-energy link is created. When the succinyl group is changed into succinate, this energy is utilized in substrate-level phosphorylation to create either guanine triphosphate (GTP) or ATP. Depending on the kind of animal tissue they are present in, there are two isoenzyme versions of the enzyme for this step. One type is present in organs like the heart and skeletal muscle that require a lot of ATP. This kind generates ATP. The liver is one of the tissues that contains a lot of anabolic pathways and hence contains the second version of the enzyme. This kind generates GTP. Energy-wise, GTP is equal to ATP, but its application is more constrained. GTP is particularly important for protein synthesis.
Step 6:
Dehydration is the sixth step, which changes succinate into fumarate. Transferring two hydrogen atoms to FAD results in FADH2. Although these atoms' electrons have enough energy to reduce FAD, they lack the necessary energy to reduce NAD+. This carrier, as opposed to NADH, stays affixed to the enzyme and directly delivers the electrons to the electron transport chain. The enzyme that catalyses this step is situated inside the inner membrane of the mitochondrion, which enables this process.
Step 7:
In step seven, fumarate is mixed with water to create malate. Oxidizing malate is the final stage in the citric acid cycle that regenerates oxaloacetate. Another NADH molecule is created.
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the origin of a new plant species by hybridizing two existing species, coupled with accidents during cell division, is an example of _____.
The origin of a new plant species by hybridizing two existing species, coupled with accidents during cell division, is an example of hybrid speciation.
Hybrid speciation occurs when two existing species hybridize and a new species forms through the accidental alterations that can occur during cell division. Hybrid Speciation: The Evolution of a New Species Through Accidental Alterations in Cell DivisionHybrid speciation is a process of natural evolution which occurs when two existing species hybridize and a new species forms through the accidental alterations that can occur during cell division. These alterations can lead to new characteristics and traits that may give the new species an advantage over existing species in the same environment.
This process is often driven by a variety of factors, such as changes in the environment, competition for resources, and even the presence of different predators. Hybridization between two species is an unpredictable event, and the new species created may be better adapted for survival. Over time, this new species may become distinct enough to be considered a separate species from its parent species, allowing it to thrive and reproduce in its own environment.
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